Endocrine Abstracts

Background: Although very rare, insulinomas are the most commonly occurring endocrine tumor of the pancreas. The aim of this study was to review the clinical presentation, diagnostic approach and management of patients with an insulinoma.Methods: 22 insulinoma patients, with an age range of 20–79, were included and evaluated according to their clinical presentation, blood biochemistry, imaging studies, operative management, pathological manifestatio...

Multiple myeloma is a neoplastic disorder arising from plasma cells in the bone marrow. Plasma cell tumors, plasmacytomas, are uncommon in the brain and occur usually in the leptomeninges with or without parencymal involvement. Extramedullary plasmacytomas are very rarely located in the sella and can be misdiagnosed as a nonfunctioning pituitary adenoma. We report an illustrative case with multiple myeloma who was diagnosed having sellar plasmacytoma resembling a nonfunctionin...

Sex reversal syndrome (SRS) is a kind of human genetic disease about gender dysplasia, which is characterised by inconsistency between gonadal sexuality and chromosome sexuality. The clinical types include 46, XY female SRS and 46, XX male SRS. The early studies of human gonadal differentiation found that human Y chromosome contains testis-determining factor (TDF) found that the sex-determining region Y (SRY) gene, which is located in Y chromosome, was the best candidate gene ...

Excessive expression of CyD1 in CCND1 gene increase G1-S phase transition and cellular proliferation. In various tumor types and of the few studies of pituitary adenomas, over expression of CyD1 or amplification in the locus of CCND1 gene, have been demonstrated. In this study, we aimed to investigate the effect of cyclin D1 gene polymorphism on tumor formation in prolactinoma patients.A hundred and thirteen patients and 108 age and gender matched contro...

In prolactinomas, today first choice of treatment is medical treatment with dopamine agonists. Cavernous sinus invasion is not uncommon in prolactinomas and stands out as a blocking factor for surgical removal of the tumor fully. In our study, the presence of cavernous sinus invasion was to investigate the effect on the results of surgical and medical treatment in prolactinomas.Eighty-seven patients followed up with a diagnosis of prolactinoma were inclu...

Prolactinomas are more common tumors by 60% among the hypophysis adenomas. These are often benign, but may present differences in terms of tumor size and treatment responses. Aim of this study was investigate the relationship of serum prolactin levels with tumor size and invasiveness in the prolactinomas.113 patients with the diagnosis of prolactinoma were included to study. Pretreatment plasma levels of prolactin in the time of diagnosis and sella MR im...

Introduction: Prolactinomas, although considered benign, show various intensity of aggressiveness. Some remain constant for whole life period while some harbour initially with invasive extension to the parasellar area. We aimed to evaluate the effect of age and gender on the invasiveness of prolactinomas.Material-methods: One hundred and thirteen patients with prolactinoma were retrospectively evaluated. Magnetic resonance images were carefully examined ...

Introduction: Fine-needle aspiration (FNA) biopsy of thyroid nodules is minimally invasive and safe. The clinical importance of the thyroid nodule evaluation is primarily related to the need to exclude thyroid cancer. We aimed to investigate the relationship between preoperative FNA cytology and results of thyroidectomy in this study.Materials and Methods: Histopathologic examination reports of 302 patients undergoing thyroidectomy and preoperative FNA c...

Benign symmetric lipomatosis (BSL) is a very rare disorder characterized by the growth of uncapsulated masses of adipose tissue, predominantly located in the neck and shoulders. Benign symmetric lipomatosis is usually described in adults between 30 and 60 years of age and is slightly more frequent in men with heavy alcohol consumption. A 70-year-old woman presented with a great growth of soft tissues in the cervico-occipital region who had never consumed any alcohol. Laborator...

A 50-year-old man admitted to our institution with labile hypertension. His blood pressure was 150/90 mmHg and the pulse rate was 96 beats per minute. He had hypertensive attacks every 2–3 days. His blood pressure was found 210/110 mmHg at hypertensive attact. He had palpable thyroid nodule. Ultrasonography of the thyroid gland showed a 2.6 cm sized, irregularly marginated, calcified thyroid nodule. His serum free thyroxine (fT4), free triiodothyronine (fT3), thyrotropin ...